Article
The cross-linking agent hexamethylphosphoramide predominantly induces intra-locus and multi-locus deletions in postmeiotic germ cells of Drosophila.
Genetics - 1 Feb 1995
Aguirrezabalaga I, Nivard M J, Comendador M A, Vogel E W
Abstract excerpt
The nature of DNA sequence changes induced by the cross-linking agent hexamethylphosphoramide (HMPA) within and in the vicinity of the vermilion locus of Drosophila melanogaster that produce a vermilion mutant phenotype was analyzed after exposure of postmeiotic male germ cells. Mutagenized males...
Topics
- Animals
- Base Sequence
- Cross-Linking Reagents
- Crosses, Genetic
- DNA Adducts
- DNA Damage
- DNA Mutational Analysis
- DNA Repair
- Drosophila melanogaster
- Female
- Genes, Lethal
- Genes, Recessive
- Hempa
- Male
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Sequence Deletion