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Article

The cross-linking agent hexamethylphosphoramide predominantly induces intra-locus and multi-locus deletions in postmeiotic germ cells of Drosophila.

Genetics - 1 Feb 1995

Aguirrezabalaga I, Nivard M J, Comendador M A, Vogel E W

Abstract excerpt

The nature of DNA sequence changes induced by the cross-linking agent hexamethylphosphoramide (HMPA) within and in the vicinity of the vermilion locus of Drosophila melanogaster that produce a vermilion mutant phenotype was analyzed after exposure of postmeiotic male germ cells. Mutagenized males were mated to either females wild-type (exr+) for nucleotide excision repair (NER) or to females having a deficiency...

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Identifiers

PMID: 7713422
DOI: 10.1093/genetics/139.2.649
PMCID: PMC1206371

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