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Article

p53 tumor suppressor gene as a clonal marker in head and neck squamous cell carcinoma: p53 mutations in primary tumor and matched lymph node metastases.

Oral oncology - 1 Jul 1999

Tjebbes G W, Leppers vd Straat F G, Tilanus M G, Hordijk G J, Slootweg P J

Abstract excerpt

In order to define the diagnostic value of p53 tumor suppressor gene as a clonal marker in head and neck squamous cell carcinoma (HNSCC), we investigated p53 mutations in primary tumors (PT) and matched lymph node metastases (LNM); the underlying question being whether differentiation between metastatic disease of a known PT or (a metastasis of) a synchronous or metachronous second tumor is possible by means of...

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PMID: 10645403
DOI: 10.1016/s1368-8375(98)00127-4

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Source receipt: pubmed, retrieved 7 Sept 2026.

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