p53 mutations in matched primary and metastatic human tumors.

doi:10.1002/mc.2940130306

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Article

p53 mutations in matched primary and metastatic human tumors.

Molecular carcinogenesis - 1 Jul 1995

Peller S, Halevy A, Slutzki S, Kopilova Y, Rotter V

Abstract excerpt

Mutations in the p53 tumor suppressor gene have been found to be the most frequent genetic alterations in human malignancies. To further examine the idea that neoplastic progression is associated with mutations in the p53 gene, we analyzed matched primary and metastatic tumor samples. The samples included 15 pairs of breast cancer and metastases to lymph nodes, four pairs of gastrointestinal adenocarcinomas and...

Topics

Adenocarcinoma
Adult
Aged
Base Sequence
Breast Neoplasms
Carcinoma, Ductal, Breast
DNA Primers
Female
Gastrointestinal Neoplasms
Genes, p53
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Molecular Sequence Data

Mutation

Neoplasm Metastasis

Sequence Deletion

Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 7619219
DOI: 10.1002/mc.2940130306

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7619219-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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