Clinical implication of screening p53 gene mutations in head and neck squamous cell carcinomas.

doi:10.1007/s004320050188

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Article

Clinical implication of screening p53 gene mutations in head and neck squamous cell carcinomas.

Journal of cancer research and clinical oncology - 1 Jan 1998

Ma L, Ronai A, Riede U N, Köhler G

Abstract excerpt

The role of the tumour-suppressor gene p53 in the tumorigenesis of head and neck cancer has been well established, but the clinical significance of p53 alteration is still unclear. A group of 50 patients with head and neck squamous cell carcinoma (HNSCC) were investigated for p53 alterations. DNA...

Topics

Biomarkers, Tumor
Carcinoma, Squamous Cell
Genes, p53
Head and Neck Neoplasms
Humans
Immunohistochemistry
Multivariate Analysis
Mutation
Predictive Value of Tests
Recurrence
Tumor Suppressor Protein p53

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