Article
Clinical implication of screening p53 gene mutations in head and neck squamous cell carcinomas.
Journal of cancer research and clinical oncology - 1 Jan 1998
Ma L, Ronai A, Riede U N, Köhler G
Abstract excerpt
The role of the tumour-suppressor gene p53 in the tumorigenesis of head and neck cancer has been well established, but the clinical significance of p53 alteration is still unclear. A group of 50 patients with head and neck squamous cell carcinoma (HNSCC) were investigated for p53 alterations. DNA was extracted from fresh tumour samples and polymerase chain reaction/single-strand conformation polymorphism analysis...
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