Article
[High incidence of p53 mutations in primary and metastatic head and neck tumors. Frequent protein overexpression in normal epithelium].
Bulletin du cancer - 1 Mar 1996
Fogel S, Ahomadegbe J C, Barrois M, Le Bihan M L, Douc-Rasy S, Duvillard P, Armand J P, Riou G
Abstract excerpt
Mutation of the p53 tumor suppressor gene is the most commonly observed gene alteration in human cancers. In order to identify new prognostic factors and tumor aggressiveness in squamous cell head and neck carcinomas, we analyzed 50 node metastases and 28 primary tumors including 13 matched speci...
Topics
- Carcinoma, Squamous Cell
- Chromosome Deletion
- DNA Mutational Analysis
- Gene Expression Regulation, Neoplastic
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Immunohistochemistry
- Mutagenesis, Insertional
- Mutation
- Neoplasm Invasiveness
- Survival Analysis