Article
Analysis of the p53 gene mutations in patients with multiple primary cancers of the oesophagus.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 1 Aug 1997
Mayama T, Mori T, Abe K, Sasano H, Nishihira T, Satomi S, Horii A
Abstract excerpt
We investigated genetic alterations of the p53 gene in two patients with multiple primary oesophageal squamous cell carcinomas (ESCs). We found that each primary tumour could be distinguished by mutation of p53. Moreover, mutations detected in the p53 gene in metastatic lymph nodes were the same...
Topics
- Aged
- Carcinoma, Squamous Cell
- Esophageal Neoplasms
- Genes, p53
- Humans
- Immunohistochemistry
- Lymphatic Metastasis
- Male
- Middle Aged
- Mutation
- Neoplasms, Multiple Primary
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Sequence Analysis, DNA