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Article

TP53 genetic heterogeneity in recurrent or second primary head and neck squamous cell carcinoma.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology - 1 Mar 2025

Kampel Liyona, Feldstein Sara, Tsuriel Shlomo, Trejo Leonor Leider, Horowitz Gilad, Warshavsky Anton, Mansour Jobran, Hershkovitz Dov, Muhanna Nidal

Abstract excerpt

Head and neck squamous cell carcinomas (HNSCC) frequently recur, and patients often develop second primary tumors. Their distinction is clinically challenging. TP53 mutational heterogeneity may indicate novel molecular events rather than resistant clones' expansion or persistent disease. Surveillance and therapeutic strategies should be adjusted, especially in the case of a second primary arising in an already...

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Topics

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Share to Carcinoma, Squamous Cell
Share to Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Heterogeneity

Share to Head and Neck Neoplasms

Share to Neoplasm Recurrence, Local

Share to Neoplasms, Second Primary

Share to Squamous Cell Carcinoma of Head and Neck

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 39800270
DOI: 10.1016/j.radonc.2025.110714

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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