Article
p53 mutation and locoregional treatment failure in head and neck squamous cell carcinoma.
Journal of the National Cancer Institute - 6 Nov 1996
Koch W M, Brennan J A, Zahurak M, Goodman S N, Westra W H, Schwab D, Yoo G H, Lee D J, Forastiere A A, Sidransky D
Abstract excerpt
BACKGROUND: The p53 gene (also known as TP53) may be the most common genetic target involved in the malignant transformation of human cells. Direct sequence analysis has demonstrated that alteration of this gene occurs in approximately 45% of head and neck squamous cell carcinomas. The consequenc...
Topics
- Carcinoma, Squamous Cell
- DNA, Neoplasm
- Disease-Free Survival
- Genes, p53
- Head and Neck Neoplasms
- Humans
- Mutation
- Polymerase Chain Reaction
- Survival Analysis
- Treatment Failure