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Article

Power of genome-wide linkage disequilibrium testing by using microsatellite markers.

Journal of human genetics - 1 Jan 2003

Ohashi Jun, Tokunaga Katsushi

Abstract excerpt

Linkage disequilibrium (LD) testing is often used in the search for disease genes. In this study, we developed a method for calculating the expected power of genome-wide LD testing by using microsatellite markers under the following assumptions: (1) microsatellite markers have unequally frequent alleles, (2) markers are equally spaced through the human genome, (3) the degree of LD between the disease variant and...

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PMID: 12938017
DOI: 10.1007/s10038-003-0058-7

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