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Article

Power of association and linkage tests when the disease alleles are unobserved.

American journal of human genetics - 1 Feb 1999

Tu I P, Whittemore A S

Abstract excerpt

Genomewide association studies have been advocated as a promising alternative to genomewide linkage scans for detection of small-effect genes in complex diseases. Comparisons of power and sample size between the two strategies have shown considerable advantages for the association studies. These comparisons assume that the set of markers includes the exact disease-related polymorphism. A concern, however, is that...

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PMID: 9973303
DOI: 10.1086/302253
PMCID: PMC1377775

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