Detecting linkage disequilibrium in the presence of locus heterogeneity.

doi:10.1111/j.1529-8817.2005.00229.x

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Article

Detecting linkage disequilibrium in the presence of locus heterogeneity.

Annals of human genetics - 1 May 2006

Wang D, Huang J

Abstract excerpt

Locus heterogeneity is a common phenomenon in complex diseases and is one of the most important factors that affect the power of either linkage or linkage disequilibrium (LD) analysis. In linkage analysis, the heterogeneity LOD score (HLOD) rather than LOD itself is often used. However, the exist...

Topics

Chromosome Mapping
Gene Frequency
Genetic Heterogeneity
Genetics, Population
Humans
Linkage Disequilibrium
Models, Genetic
Polymorphism, Single Nucleotide

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