An evaluation of different meta-analysis approaches in the presence of allelic heterogeneity.

Abstract excerpt

Meta-analysis has proven a useful tool in genetic association studies. Allelic heterogeneity can arise from ethnic background differences across populations being meta-analyzed (for example, in search of common frequency variants through genome-wide association studies), and through the presence of multiple low frequency and rare associated variants in the same functional unit of interest (for example, within a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Genetic Heterogeneity