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Article

Power of genetic association studies in the presence of linkage disequilibrium and allelic heterogeneity.

Human heredity - 1 Jan 2008

Fisher Sheila A, Lewis Cathryn M

Abstract excerpt

OBJECTIVES: The calculation of the power and sample size required for association studies is essential, particularly for follow-up of genome-wide association studies, where much genotyping is required to replicate the original finding and identify the true disease susceptibility mutation. METHODS: In this paper, we derive equations for estimation of sample sizes for the transmission disequilibrium test (TDT) and...

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Identifiers

PMID: 18612206
DOI: 10.1159/000143404
PMCID: PMC2787185

Genes

NOD2
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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