Article
Required sample size and nonreplicability thresholds for heterogeneous genetic associations.
Proceedings of the National Academy of Sciences of the United States of America - 15 Jan 2008
Moonesinghe Ramal, Khoury Muin J, Liu Tiebin, Ioannidis John P A
Abstract excerpt
Many gene-disease associations proposed to date have not been consistently replicated across different populations. Nonreplication often reflects false positives in the original claims. However, occasionally, nonreplication may be due to heterogeneity due to biases or even genuine diversity of the genetic effects in different populations. Here, we propose methods for estimating the required sample size to...
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