Article
Blocking P-selectin protects from ischemia/reperfusion-induced acute renal failure.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2000
Singbartl K, Green S A, Ley K
Abstract excerpt
Acute renal failure (ARF) in response to ischemia-reperfusion is thought to be associated with neutrophil infiltration. Neutrophil recruitment depends on adhesion molecules, including P-selectin. Our study sought to characterize the role of P-selectin in ischemia-reperfusion (I/R) -induced acute renal failure (ARF). In wild-type (wt) and P-selectin-deficient (P-/-) mice (both C57BL/6), ARF was induced by 32 min...
Topics
- Acute Kidney Injury
- Animals
- Antibodies, Monoclonal
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation
- Neutrophils
- P-Selectin
- Reperfusion Injury