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Article

p53 is renoprotective after ischemic kidney injury by reducing inflammation.

Journal of the American Society of Nephrology : JASN - 1 Jan 2013

Sutton Timothy A, Hato Takashi, Mai Erik, Yoshimoto Momoko, Kuehl Sarah, Anderson Melissa, Mang Henry, Plotkin Zoya, Chan Rebecca J, Dagher Pierre C

Abstract excerpt

In the rat, p53 promotes tubular apoptosis after ischemic AKI. Acute pharmacologic inhibition of p53 is protective in this setting, but chronic inhibition enhances fibrosis, demonstrating that the role of p53 in ischemic AKI is incompletely understood. Here, we investigated whether genetic absence of p53 is also protective in ischemic AKI. Surprisingly, p53-knockout mice (p53(-/-)) had worse kidney injury,...

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Identifiers

PMID: 23222126
DOI: 10.1681/ASN.2012050469
PMCID: PMC3537213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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