Article
Antithrombin III/SerpinC1 insufficiency exacerbates renal ischemia/reperfusion injury.
Kidney international - 1 Oct 2015
Wang Feng, Zhang Guangyuan, Lu Zeyuan, Geurts Aron M, Usa Kristie, Jacob Howard J, Cowley Allen W, Wang Niansong, Liang Mingyu
Abstract excerpt
Antithrombin III, encoded by SerpinC1, is a major anti-coagulation molecule in vivo and has anti-inflammatory effects. We found that patients with low antithrombin III activities presented a higher risk of developing acute kidney injury after cardiac surgery. To study this further, we generated SerpinC1 heterozygous knockout rats and followed the development of acute kidney injury in a model of modest renal...
Topics
- Acute Kidney Injury
- Aged
- Animals
- Antithrombin III
- Antithrombin III Deficiency
- Apoptosis
- Biomarkers
- Cardiac Surgical Procedures
- Creatinine
- Disease Models, Animal
- Female