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Article

Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage.

Scientific reports - 29 Aug 2017

Gai Zhibo, Chu Lei, Xu Zhenqiang, Song Xiaoming, Sun Dongfeng, Kullak-Ublick Gerd A

Abstract excerpt

Farnesoid X receptor (FXR) activation has been reported to reduce inflammation and oxidative stress. Because both inflammation and oxidative stress are critical for tissue destruction during kidney ischemia reperfusion (I/R) injury, we investigated the protective role of FXR against kidney damage induced by I/R in mice. Mice undergoing renal I/R developed the typical features of acute kidney injury (AKI):...

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Identifiers

PMID: 28852062
DOI: 10.1038/s41598-017-10168-6
PMCID: PMC5575310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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