Article
Soluble thrombomodulin protects ischemic kidneys.
Journal of the American Society of Nephrology : JASN - 1 Mar 2009
Sharfuddin Asif A, Sandoval Ruben M, Berg David T, McDougal Grant E, Campos Silvia B, Phillips Carrie L, Jones Bryan E, Gupta Akanksha, Grinnell Brian W, Molitoris Bruce A
Abstract excerpt
Altered coagulation and inflammation contribute to the pathogenesis of ischemic renal injury. Thrombomodulin is a necessary factor in the anticoagulant protein C pathway and has inherent anti-inflammatory properties. We studied the effect of soluble thrombomodulin (sTM) in a hypoperfusion model of ischemic kidney injury. To markedly reduce infrarenal aortic blood flow and femoral arterial pressures, we clamped...
Topics
- Animals
- Base Sequence
- Capillary Permeability
- Cell Adhesion
- DNA Primers
- Fibrinolytic Agents
- Genetic Variation
- Ischemia
- Kidney
- Kidney Tubular Necrosis, Acute
- Leukocytes
- Male
- Protein C
- Rats