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Article

Soluble thrombomodulin protects ischemic kidneys.

Journal of the American Society of Nephrology : JASN - 1 Mar 2009

Sharfuddin Asif A, Sandoval Ruben M, Berg David T, McDougal Grant E, Campos Silvia B, Phillips Carrie L, Jones Bryan E, Gupta Akanksha, Grinnell Brian W, Molitoris Bruce A

Abstract excerpt

Altered coagulation and inflammation contribute to the pathogenesis of ischemic renal injury. Thrombomodulin is a necessary factor in the anticoagulant protein C pathway and has inherent anti-inflammatory properties. We studied the effect of soluble thrombomodulin (sTM) in a hypoperfusion model of ischemic kidney injury. To markedly reduce infrarenal aortic blood flow and femoral arterial pressures, we clamped...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19176699
DOI: 10.1681/ASN.2008060593
PMCID: PMC2653675

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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