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Article

IL-17 mediates neutrophil infiltration and renal fibrosis following recovery from ischemia reperfusion: compensatory role of natural killer cells in athymic rats.

American journal of physiology. Renal physiology - 1 Mar 2017

Mehrotra Purvi, Collett Jason A, McKinney Seth D, Stevens Jackson, Ivancic Carlie M, Basile David P

Abstract excerpt

T cells have been implicated in the pathogenesis of acute kidney injury (AKI) and its progression to chronic kidney disease (CKD). Previous studies suggest that Th17 cells participate during the AKI-to-CKD transition, and inhibition of T cell activity by mycophenolate mofetil (MMF) or losartan attenuates the development of fibrosis following AKI. We hypothesized that T cell-deficient rats may have reduced levels...

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Identifiers

PMID: 27852609
DOI: 10.1152/ajprenal.00462.2016
PMCID: PMC5374313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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