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Article

Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells.

The Journal of clinical investigation - 1 Sept 2003

Day Yuan-Ji, Huang Liping, McDuffie Marcia J, Rosin Diane L, Ye Hong, Chen Jiang-Fan, Schwarzschild Michael A, Fink J Stephen, Linden Joel, Okusa Mark D

Abstract excerpt

Activation of A2A adenosine receptors (A2ARs) protects kidneys from ischemia-reperfusion injury (IRI). A2ARs are expressed on bone marrow-derived (BM-derived) cells and renal smooth muscle, epithelial, and endothelial cells. To measure the contribution of A2ARs on BM-derived cells in suppressing renal IRI, we examined the effects of a selective agonist of A2ARs, ATL146e, in chimeric mice in which BM was ablated...

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Identifiers

PMID: 12975473
DOI: 10.1172/JCI15483
PMCID: PMC193661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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