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Article

Mutational analysis of the Caenorhabditis elegans cell-death gene ced-3.

Genetics - 1 Dec 1999

Shaham S, Reddien P W, Davies B, Horvitz H R

Abstract excerpt

Mutations in the gene ced-3, which encodes a protease similar to interleukin-1beta converting enzyme and related proteins termed caspases, prevent programmed cell death in the nematode Caenorhabditis elegans. We used site-directed mutagenesis to demonstrate that both the presumptive active-site cysteine of the CED-3 protease and the aspartate residues at sites of processing of the CED-3 proprotein are required...

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Identifiers

PMID: 10581274
DOI: 10.1093/genetics/153.4.1655
PMCID: PMC1460877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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