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Article

Essential role of CED-4 oligomerization in CED-3 activation and apoptosis.

Science (New York, N.Y.) - 28 Aug 1998

Yang X, Chang H Y, Baltimore D

Abstract excerpt

Control of the activation of apoptosis is important both in development and in protection against cancer. In the classic genetic model Caenorhabditis elegans, the pro-apoptotic protein CED-4 activates the CED-3 caspase and is inhibited by the Bcl-2-like protein CED-9. Both processes are mediated by protein-protein interaction. Facilitating the proximity of CED-3 zymogen molecules was found to induce caspase...

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Identifiers

PMID: 9721101
DOI: 10.1126/science.281.5381.1355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Essential role of CED-4 oligomerization in CED-3 activation and apoptosis.PMID 9721101Read ↗

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death.Semantic proximity Read ↗

Oligomerized Ced-4 kills budding yeast through a caspase-independent mechanism.Semantic proximity Read ↗

The pro-apoptotic function of the C. elegans BCL-2 homolog CED-9 requires interaction with the APAF-1 homolog CED-4.Semantic proximity Read ↗

Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3.Semantic proximity Read ↗

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death.Semantic proximity Read ↗

Interaction and regulation of subcellular localization of CED-4 by CED-9.Semantic proximity Read ↗

CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans.Semantic proximity Read ↗

The ins and outs of programmed cell death during C. elegans development.Semantic proximity Read ↗

Proapoptotic activity of Caenorhabditis elegans CED-4 protein in Drosophila: implicated mechanisms for caspase activation.Semantic proximity Read ↗

Suppression of CED-3-independent apoptosis by mitochondrial betaNAC in Caenorhabditis elegans.Semantic proximity Read ↗

Noncanonical cell death programs in the nematode Caenorhabditis elegans.Semantic proximity Read ↗

Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities.Semantic proximity Read ↗

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