Essential role of CED-4 oligomerization in CED-3 activation and apoptosis.

doi:10.1126/science.281.5381.1355

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Article

Essential role of CED-4 oligomerization in CED-3 activation and apoptosis.

Science (New York, N.Y.) - 28 Aug 1998

Yang X, Chang H Y, Baltimore D

Abstract excerpt

Control of the activation of apoptosis is important both in development and in protection against cancer. In the classic genetic model Caenorhabditis elegans, the pro-apoptotic protein CED-4 activates the CED-3 caspase and is inhibited by the Bcl-2-like protein CED-9. Both processes are mediated...

Topics

Apoptosis
Apoptosis Regulatory Proteins
Biopolymers
Caenorhabditis elegans Proteins
Calcium-Binding Proteins
Caspases
Cell Line
Chemical Phenomena
Chemistry, Physical
Cysteine Endopeptidases
Cysteine Proteinase Inhibitors
Enzyme Activation
Enzyme Precursors
HeLa Cells
Helminth Proteins
Humans
Mutation
Oligopeptides

Source

Open in PubMed

Identifiers

PMID: 9721101
DOI: 10.1126/science.281.5381.1355

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9721101-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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