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Article

Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3.

Nature structural & molecular biology - 1 Oct 2008

Geng Xin, Shi Yong, Nakagawa Akihisa, Yoshina Sawako, Mitani Shohei, Shi Yigong, Xue Ding

Abstract excerpt

Inhibitor of apoptosis (IAP) proteins have a crucial role in apoptosis, through negative regulation of caspases in species from fruitflies to mammals. In Caenorhabditis elegans, however, no IAP homolog or caspase inhibitor has been identified, calling into question how the cell-killing caspase CE...

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PMID: 18776901
DOI: 10.1038/nsmb.1488
PMCID: PMC2574878

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-18776901-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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