Article
Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans.
The Journal of biological chemistry - 1 Sept 2000
del Peso L, Gonzalez V M, Inohara N, Ellis R E, Núñez G
Abstract excerpt
In the nematode Caenorhabditis elegans, the apoptotic machinery is composed of four basic elements: the caspase CED-3, the Apaf-1 homologue CED-4, and the Bcl-2 family members CED-9 and EGL-1. The ced-9(n1950) gain-of-function mutation prevents most, if not all, somatic cell deaths in C. elegans. It encodes a CED-9 protein with a glycine-to-glutamate substitution at position 169, which is located within the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.