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Article

Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing.

Proceedings of the National Academy of Sciences of the United States of America - 27 Feb 2001

Aballay A, Ausubel F M

Abstract excerpt

Programmed cell death (PCD) in mammals has been implicated in several disease states including cancer, autoimmune disease, and neurodegenerative disease. In Caenorhabditis elegans, PCD is a normal component of development. We find that Salmonella typhimurium colonization of the C. elegans intestine leads to an increased level of cell death in the worm gonad. S. typhimurium-mediated germ-line cell death is not...

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Identifiers

PMID: 11226309
DOI: 10.1073/pnas.041613098
PMCID: PMC30208

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