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Article

Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death.

Science (New York, N.Y.) - 21 Feb 1997

Chinnaiyan A M, O'Rourke K, Lane B R, Dixit V M

Abstract excerpt

Previous genetic studies of the nematode Caenorhabditis elegans identified three important components of the cell death machinery. CED-3 and CED-4 function to kill cells, whereas CED-9 protects cells from death. Here CED-9 and its mammalian homolog Bcl-xL (a member of the Bcl-2 family of cell death regulators) were both found to interact with and inhibit the function of CED-4. In addition, analysis revealed that...

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PMID: 9027312
DOI: 10.1126/science.275.5303.1122

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Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death.PMID 9027312Read ↗

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