Article
Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death.
Science (New York, N.Y.) - 21 Feb 1997
Chinnaiyan A M, O'Rourke K, Lane B R, Dixit V M
Abstract excerpt
Previous genetic studies of the nematode Caenorhabditis elegans identified three important components of the cell death machinery. CED-3 and CED-4 function to kill cells, whereas CED-9 protects cells from death. Here CED-9 and its mammalian homolog Bcl-xL (a member of the Bcl-2 family of cell dea...
Topics
- Animals
- Apoptosis
- Apoptosis Regulatory Proteins
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Calcium-Binding Proteins
- Caspase 1
- Caspase 8
- Caspase 9
- Caspases
- Cell Line
- Cysteine Endopeptidases
- Genes, Helminth
- Helminth Proteins
- Humans
- Mutation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-bcl-2