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Article

The ins and outs of programmed cell death during C. elegans development.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 30 Aug 1994

Hengartner M O, Horvitz H R

Abstract excerpt

During the development of the C. elegans hermaphrodite, 131 of the 1090 cells generated undergo programmed cell death. Genetic studies have identified mutations in 14 genes that specifically affect this process. These genes define a genetic pathway for programmed cell death in C. elegans. Two genes, ced-3 and ced-4, are required for cells to undergo programmed cell death, while a third gene, ced-9, protects cells...

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PMID: 7846120
DOI: 10.1098/rstb.1994.0100

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