Article
High rate of small TP53 mutations and infrequent loss of heterozygosity in malignant liver tumors associated with thorotrast: implications for alpha-particle carcinogenesis.
Radiation research - 1 Dec 1999
Wada I, Horiuchi H, Mori M, Ishikawa Y, Fukumoto M, Mori T, Kato Y, Kitagawa T, Machinami R
Abstract excerpt
Epidemiological studies have revealed that malignant tumors occur in the liver approximately 20 years after injection of Thorotrast. We investigated genetic changes in the TP53 gene (formerly known as p53) in malignant liver tumors related to Thorotrast to cast light on the mechanisms of alpha-particle carcinogenesis. A total of 19 autopsy cases of liver malignancies [11 hepatocellular carcinomas (HCC), 5...
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