Multiple, unique, and common p53 mutations in a thorotrast recipient with four primary cancers.

doi:10.1016/s0046-8177(98)90126-5

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Multiple, unique, and common p53 mutations in a thorotrast recipient with four primary cancers.

Human pathology - 1 Apr 1998

Iwamoto K S, Mizuno T, Kurata A, Masuzawa M, Mori T, Seyama T

Abstract excerpt

Four primary cancers found at autopsy of a patient who received the thorium-based contrast agent Thorotrast 50 years ago and who was healthy up until a few months before his death from liver failure were analyzed for p53 mutations. The data suggest that the chronic alpha-irradiation may be a large causative factor. Multiple mutations were found in all the cancer tissues: two foci of a cholangiocellular carcinoma,...

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Multiple, unique, and common p53 mutations in a thorotrast recipient with four primary cancers.

Abstract excerpt

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