Article
Mutations of p53 tumor-suppressor gene in angiosarcoma.
International journal of cancer - 11 Jun 1997
Naka N, Tomita Y, Nakanishi H, Araki N, Hongyo T, Ochi T, Aozasa K
Abstract excerpt
Transgenic mice deficient for the p53 gene were reported to frequently develop angiosarcoma (AS), suggesting that alterations in the gene are associated with tumorigenesis of AS. However, little is known about genetic changes, including p53 gene alterations, in human AS because of its rarity. We analyzed p53 mutations on paraffin-embedded specimens from 33 patients with AS by polymerase chain...
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