Article
p53 gene mutation spectrum in hepatocellular carcinoma.
Cancer research - 15 Nov 1992
Oda T, Tsuda H, Scarpa A, Sakamoto M, Hirohashi S
Abstract excerpt
In order to clarify the significance of mutation of the p53 tumor suppressor gene in the genesis and development of human hepatocellular carcinoma (HCC) in an aflatoxin B1 low-exposure area, the spectrum, i.e., incidence, type, and site, of p53 gene mutations was examined in 169 tissue samples resected mainly from Japanese patients using single-strand conformation polymorphism analysis and direct sequencing....
Topics
- Adult
- Aged
- Carcinoma, Hepatocellular
- Cell Differentiation
- Chromosomes, Human, Pair 17
- Codon
- Female
- Genes, p53
- Hepatitis B
- Hepatitis C
- Heterozygote
- Humans