Article
p53 mutations at A:T base pairs in angiosarcomas of vinyl chloride-exposed factory workers.
Carcinogenesis - 1 Jan 1994
Hollstein M, Marion M J, Lehman T, Welsh J, Harris C C, Martel-Planche G, Kusters I, Montesano R
Abstract excerpt
Mutations in the p53 tumor suppressor gene are commonly found in the major human cancers and the mutational spectrum in some cancer types is consistent with the genotoxic effects of the associated environmental risk factors. Thus far there is little information on p53 mutations in cancers of fact...
Topics
- Adenine
- Aged
- Base Composition
- Base Sequence
- Carcinoma, Hepatocellular
- DNA
- Exons
- Gene Amplification
- Genes, p53
- Hemangiosarcoma
- Humans
- Liver Neoplasms
- Middle Aged
- Mutation
- Neoplasm Proteins
- Nuclear Proteins
- Occupational Diseases
- Polymerase Chain Reaction