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Article

Melanoma loss-of-function mutants in Xiphophorus caused by Xmrk-oncogene deletion and gene disruption by a transposable element.

Genetics - 1 Nov 1999

Schartl M, Hornung U, Gutbrod H, Volff J N, Wittbrodt J

Abstract excerpt

The overexpression of the Xmrk oncogene (ONC-Xmrk) in pigment cells of certain Xiphophorus hybrids has been found to be the primary change that results in the formation of malignant melanoma. Spontaneous mutant stocks have been isolated that have lost the ability to induce tumor formation when crossed with Xiphophorus helleri. Two of these loss-of-function mutants were analyzed for genetic defects in ONC-Xmrk's....

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Identifiers

PMID: 10545466
DOI: 10.1093/genetics/153.3.1385
PMCID: PMC1460825

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