From Mendelian to molecular genetics: the Xiphophorus melanoma model.

doi:10.1016/j.tig.2006.09.013

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Article

From Mendelian to molecular genetics: the Xiphophorus melanoma model.

Trends in genetics : TIG - 1 Dec 2006

Meierjohann Svenja, Schartl Manfred

Abstract excerpt

In human tumor biopsies it is almost impossible to pinpoint the particular molecular abnormalities that determine neoplasia. In animal models where tumorigenesis is initiated by clearly defined genetic events, it is possible to study the genes and their functions that make a normal cell become a fully malignant cancer cell. In the fish Xiphophorus, melanoma can be initiated by simple crossings, and the signaling...

Topics

Animals
Cyprinodontiformes
Disease Models, Animal
Disease Progression
Evolution, Molecular
Fish Proteins
Gene Expression Regulation, Neoplastic
Genetic Variation
Humans
Melanoma
Models, Biological
Models, Genetic
Neoplasms
Receptor Protein-Tyrosine Kinases
Signal Transduction
Systems Biology

Source

Open in PubMed

Identifiers

PMID: 17034900
DOI: 10.1016/j.tig.2006.09.013

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