Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activating mutations in the extracellular domain of the melanoma inducing receptor Xmrk are tumorigenic in vivo.

International journal of cancer - 10 Dec 2005

Winnemoeller Dirk, Wellbrock Claudia, Schartl Manfred

Abstract excerpt

Mutated versions or overexpression of receptor tyrosine kinases such as the epidermal growth factor receptor are found frequently in various cancers. In Xiphophorus the formation of hereditary melanoma is caused by the overexpression of the Xmrk oncogene locus. Xmrk is a mutationally altered version of the epidermal growth factor receptor. Two amino acid changes in the extracellular domain of the receptor were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Fish Proteins
Share to EGF gene
Share to Melanoma, Experimental

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Oryzias

Share to Receptor Protein-Tyrosine Kinases

Source

Identifiers

PMID: 15957173
DOI: 10.1002/ijc.21232

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activating mutations in the extracellular domain of the melanoma inducing receptor Xmrk are tumorigenic in vivo.PMID 15957173Read ↗

Activation of the Xmrk proto-oncogene of Xiphophorus by overexpression and mutational alterations.Semantic proximity Read ↗

Ligand-independent dimerization and activation of the oncogenic Xmrk receptor by two mutations in the extracellular domain.Semantic proximity Read ↗

Expression regulation triggers oncogenicity of xmrk alleles in the Xiphophorus melanoma system.Semantic proximity Read ↗

Tumor induction and tumor regression in Xiphophorus.Semantic proximity Read ↗

Melanoma loss-of-function mutants in Xiphophorus caused by Xmrk-oncogene deletion and gene disruption by a transposable element.Semantic proximity Read ↗

Functional Test of a Naturally Occurred Tumor Modifier Gene Provides Insights to Melanoma DevelopmentSemantic proximity Read ↗

Transcriptional background effects on a tumor driver gene in a transgenic medaka melanoma modelSemantic proximity Read ↗

Transcriptional control analyses of the Xiphophorus melanoma oncogene.Semantic proximity Read ↗

Functional test of a naturally occurred tumor modifier gene provides insights to melanoma development.Semantic proximity Read ↗

Xmrks the Spot: Fish Models for Investigating Epidermal Growth Factor Receptor Signaling in Cancer ResearchSemantic proximity Read ↗

Selection for a dominant oncogene and large male size as a risk factor for melanoma in the Xiphophorus animal model.Semantic proximity Read ↗

Increasing melanoma incidence: putatively explainable by retrotransposons. Experimental contributions of the xiphophorine Gordon-Kosswig melanoma system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.