Article
Tumor induction and tumor regression in Xiphophorus.
In vivo (Athens, Greece) - 1 Jan 2000
Schartl A, Schartl M
Abstract excerpt
Spontaneous melanoma in hybrids of Xiphophorus is caused by overexpression of the receptor tyrosine kinase gene Xmrk. In rare cases melanoma also occurs in non-hybrid fish from natural habitats where the trigger is unknown. In these tumors Xmrk is overexpressed too, pointing to a similar molecular mechanism underlying neoplastic transformation. After carcinogen treatment a variety of tumor of other histiotypes...
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