Activation of the Xmrk proto-oncogene of Xiphophorus by overexpression and mutational alterations.

doi:10.1038/sj.onc.1201693

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Article

Activation of the Xmrk proto-oncogene of Xiphophorus by overexpression and mutational alterations.

Oncogene - 2 Apr 1998

Dimitrijevic N, Winkler C, Wellbrock C, Gómez A, Duschl J, Altschmied J, Schartl M

Abstract excerpt

Xmrk is a receptor tyrosine kinase closely related to the human EGF receptor. In the teleost fish Xiphophorus two versions of the Xmrk gene exist, an oncogene (ONC) and a proto-oncogene (INV). While ONC-Xmrk is the melanoma-inducing gene, INV-Xmrk appears not to be involved in transformation of p...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cyprinodontiformes
DNA
Fish Proteins
Gene Expression Regulation, Neoplastic
Molecular Sequence Data
Mutation
Oncogenes
Proto-Oncogene Mas
Proto-Oncogenes
Receptor Protein-Tyrosine Kinases
Sequence Homology, Amino Acid
Sequence Homology, Nucleic Acid
Tumor Cells, Cultured

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PMID: 9582016
DOI: 10.1038/sj.onc.1201693

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9582016-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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