Article
Functional test of a naturally occurred tumor modifier gene provides insights to melanoma development.
G3 (Bethesda, Md.) - 5 Feb 2025
Garcia-Olazabal Mateo, Adolfi Mateus Contar, Wilde Brigitta, Hufnagel Anita, Paudel Rupesh, Lu Yuan, Meierjohann Svenja, Rosenthal Gil G, Schartl Manfred
Abstract excerpt
Occurrence of degenerative interactions is thought to serve as a mechanism underlying hybrid unfitness in most animal systems. However, the molecular mechanisms underpinning the genetic interaction and how they contribute to overall hybrid incompatibilities are limited to only a handful of examples. A vertebrate model organism, Xiphophorus, is used to study hybrid dysfunction, and it has been shown from this...
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