Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The macromelanophore locus and the melanoma oncogene Xmrk are separate genetic entities in the genome of Xiphophorus.

Genetics - 1 Aug 1998

Weis S, Schartl M

Abstract excerpt

Fish of the genus Xiphophorus are polymorphic for black pigmentation patterns. Certain intra- or interspecific hybrids exhibit enhanced expression of these patterns, leading in many cases to malignant melanoma. Because no recombination was ever observed between the pattern information and the genetic predisposition to develop melanoma after hybridization, a "tumor gene" (Tu) was postulated that encodes both...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Crosses, Genetic
Share to DNA

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Primers

Share to Molecular Sequence Data

Share to Oncogenes

Share to Phenotype

Share to Phylogeny

Source

Open in PubMed Open full text

Identifiers

PMID: 9691046
DOI: 10.1093/genetics/149.4.1909
PMCID: PMC1460281

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The macromelanophore locus and the melanoma oncogene Xmrk are separate genetic entities in the genome of Xiphophorus.PMID 9691046Read ↗

Melanoma loss-of-function mutants in Xiphophorus caused by Xmrk-oncogene deletion and gene disruption by a transposable element.Semantic proximity Read ↗

Expression regulation triggers oncogenicity of xmrk alleles in the Xiphophorus melanoma system.Semantic proximity Read ↗

Functional Test of a Naturally Occurred Tumor Modifier Gene Provides Insights to Melanoma DevelopmentSemantic proximity Read ↗

Functional test of a naturally occurred tumor modifier gene provides insights to melanoma development.Semantic proximity Read ↗

Tumor induction and tumor regression in Xiphophorus.Semantic proximity Read ↗

Mate choice for more melanin as a mechanism to maintain a functional oncogene.Semantic proximity Read ↗

Transcriptional background effects on a tumor driver gene in a transgenic medaka melanoma modelSemantic proximity Read ↗

Segregation between an ornamental and a disease driver gene provides insights into pigment cell regulationSemantic proximity Read ↗

A cancer-causing gene is positively correlated with male aggression in Xiphophorus cortezi.Semantic proximity Read ↗

Activation of the Xmrk proto-oncogene of Xiphophorus by overexpression and mutational alterations.Semantic proximity Read ↗

Transcriptional control analyses of the Xiphophorus melanoma oncogene.Semantic proximity Read ↗

MNU induction of neoplasia in a platyfish model.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.