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Article

Transcriptional control analyses of the Xiphophorus melanoma oncogene.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP - 1 Dec 2015

Regneri Janine, Volff Jean-Nicolas, Schartl Manfred

Abstract excerpt

Melanoma development in interspecific hybrids of Xiphophorus is induced by the overexpression of the mutationally activated receptor tyrosine kinase Xmrk in pigment cells. Based on the melanocyte specificity of the transcriptional upregulation, a pigment cell-specific promoter region was postulated for xmrk, the activity of which is controlled in healthy purebred fish by the molecularly still unidentified...

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Identifiers

PMID: 26348392
DOI: 10.1016/j.cbpc.2015.09.001
PMCID: PMC4662873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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