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Article

Expression regulation triggers oncogenicity of xmrk alleles in the Xiphophorus melanoma system.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP - 1 Jan 2012

Regneri Janine, Schartl Manfred

Abstract excerpt

The Xiphophorus melanoma model has gained attention in biomedical research as a genetic model for tumor formation. Melanoma development in interspecific hybrids of Xiphophorus is connected to pigment cell specific overexpression of the mutationally activated receptor tyrosine kinase Xmrk. In purebred fish the oncogenic function of xmrk is suppressed by a so far unknown regulator locus R. To test the hypothesis...

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Identifiers

PMID: 21527356
DOI: 10.1016/j.cbpc.2011.04.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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