Article
Increasing melanoma incidence: putatively explainable by retrotransposons. Experimental contributions of the xiphophorine Gordon-Kosswig melanoma system.
Pigment cell research - 1 Dec 1994
Anders A, Petry H, Fleming C, Petry K, Brix P, Lüke W, Gröger H, Schneider E, Kiefer J, Anders F
Abstract excerpt
The worldwide accelerating increase of neoplasia in humans is difficult to explain. We use the Xiphophorus tumor model to approach this problem by melanoma provocation with X-rays. Melanoma develops following inappropriate expression of x-erb B-conducted developmental genes and their controllers. These oncodeterminants are inherited according to Mendelian rules. We detected a new type of oncodeterminants that,...
Topics
- Animals
- Base Sequence
- Carcinogens
- Chromosomes
- Crosses, Genetic
- Cyprinodontiformes
- DNA Transposable Elements
- Embryo, Nonmammalian
- Female
- Fish Diseases
- Gene Expression Regulation, Neoplastic