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Article

Identification of RNA-binding surfaces in iron regulatory protein-1.

The EMBO journal - 1 Nov 1999

Kaldy P, Menotti E, Moret R, Kühn L C

Abstract excerpt

Post-transcriptional regulation of mRNA translation and stability in iron metabolism involves the interaction between the trans-acting cytoplasmic iron regulatory proteins (IRP-1 and IRP-2) and cis-acting iron-responsive elements (IREs) in mRNA 5'- or 3'-untranslated regions. IRP-1 can adopt two conformations: one with a [4Fe-4S]-cluster, unable to bind IREs, which functions as a cytoplasmic aconitase; one...

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Identifiers

PMID: 10545118
DOI: 10.1093/emboj/18.21.6073
PMCID: PMC1171672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification of RNA-binding surfaces in iron regulatory protein-1.PMID 10545118Read ↗

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Iron-responsive degradation of iron-regulatory protein 1 does not require the Fe-S cluster.Semantic proximity Read ↗

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The 5'-untranslated region of human transferrin mRNA, which contains a putative iron-regulatory element, is bound by purified iron-regulatory protein in a sequence-specific manner.Semantic proximity Read ↗

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