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Article

Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling.

The Journal of biological chemistry - 8 May 2009

Deck Kathryn M, Vasanthakumar Aparna, Anderson Sheila A, Goforth Jeremy B, Kennedy M Claire, Antholine William E, Eisenstein Richard S

Abstract excerpt

Iron-sulfur cluster-dependent interconversion of iron regulatory protein 1 (IRP1) between its RNA binding and cytosolic aconitase (c-acon) forms controls vertebrate iron homeostasis. Cluster removal from c-acon is thought to include oxidative demetallation as a required step, but little else is understood about the process of conversion to IRP1. In comparison with c-acon(WT), Ser(138) phosphomimetic mutants of...

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Identifiers

PMID: 19269970
DOI: 10.1074/jbc.M807717200
PMCID: PMC2675999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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Evidence that phosphorylation of iron regulatory protein 1 at Serine 138 destabilizes the [4Fe-4S] cluster in cytosolic aconitase by enhancing 4Fe-3Fe cycling.PMID 19269970Read ↗

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