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Article

IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities.

The Biochemical journal - 15 May 2005

Fillebeen Carine, Caltagirone Annie, Martelli Alain, Moulis Jean-Marc, Pantopoulos Kostas

Abstract excerpt

In iron-starved cells, IRP1 (iron regulatory protein 1) binds to mRNA iron-responsive elements and controls their translation or stability. In response to increased iron levels, RNA-binding is inhibited on assembly of a cubane [4Fe-4S] cluster, which renders IRP1 to a cytosolic aconitase. Phosphorylation at conserved serine residues may also regulate the activities of IRP1. We demonstrate that Ser-711 is a...

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Identifiers

PMID: 15636585
DOI: 10.1042/BJ20041623
PMCID: PMC1186702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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IRP1 Ser-711 is a phosphorylation site, critical for regulation of RNA-binding and aconitase activities.PMID 15636585Read ↗

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