Article
Structural requirements of iron-responsive elements for binding of the protein involved in both transferrin receptor and ferritin mRNA post-transcriptional regulation.
Nucleic acids research - 11 Apr 1990
Leibold E A, Laudano A, Yu Y
Abstract excerpt
The synthesis of both transferrin receptor (TfR) and ferritin is regulated post-transcriptionally by iron. This is mediated by iron responsive elements (IREs) in the 5'- and 3'-untranslated regions, respectively, of TfR and ferritin mRNAs. Although these IREs have different sequences, they both f...
Topics
- Animals
- Base Sequence
- Carrier Proteins
- Cytosol
- Ferritins
- Gene Expression Regulation
- Iron
- Liver
- Male
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA Processing, Post-Transcriptional
- RNA, Messenger
- Rats
- Rats, Inbred Strains
- Receptors, Transferrin
- Transcription, Genetic