Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural requirements of iron-responsive elements for binding of the protein involved in both transferrin receptor and ferritin mRNA post-transcriptional regulation.

Nucleic acids research - 11 Apr 1990

Leibold E A, Laudano A, Yu Y

Abstract excerpt

The synthesis of both transferrin receptor (TfR) and ferritin is regulated post-transcriptionally by iron. This is mediated by iron responsive elements (IREs) in the 5'- and 3'-untranslated regions, respectively, of TfR and ferritin mRNAs. Although these IREs have different sequences, they both form a characteristic stem-loop. We used competition assays and partial peptide mapping of UV-crosslinked ferritin and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Molecular Sequence Data

Share to Mutation

Share to RNA, Messenger

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2336358
DOI: 10.1093/nar/18.7.1819
PMCID: PMC330601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Structural requirements of iron-responsive elements for binding of the protein involved in both transferrin receptor and ferritin mRNA post-transcriptional regulation.PMID 2336358Read ↗

Role of RNA secondary structure of the iron-responsive element in translational regulation of ferritin synthesis.Semantic proximity Read ↗

The 5'-untranslated region of human transferrin mRNA, which contains a putative iron-regulatory element, is bound by purified iron-regulatory protein in a sequence-specific manner.Semantic proximity Read ↗

Post-transcriptional control via iron-responsive elements: the impact of aberrations in hereditary disease.Semantic proximity Read ↗

Probing the structure of the regulatory region of human transferrin receptor messenger RNA and its interaction with iron regulatory protein-1.Semantic proximity Read ↗

The importance of a single G in the hairpin loop of the iron responsive element (IRE) in ferritin mRNA for structure: an NMR spectroscopy study.Semantic proximity Read ↗

The Non-Canonical Iron-Responsive Element of IRE-tvcp12 Hairpin Structure at the 3′-UTR of Trichomonas vaginalis TvCP12 mRNA That Binds TvHSP70 and TvACTN-3 Can Regulate mRNA Stability and Amount of ProteinSemantic proximity Read ↗

Identification of RNA-binding surfaces in iron regulatory protein-1.Semantic proximity Read ↗

Defining a novel cis element in the 3'-untranslated region of mammalian ribonucleotide reductase component R2 mRNA: role in transforming growth factor-beta 1 induced mRNA stabilization.Semantic proximity Read ↗

The trichomonad cysteine proteinase TVCP4 transcript contains an iron‐responsive elementSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.