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Article

Probing the structure of the regulatory region of human transferrin receptor messenger RNA and its interaction with iron regulatory protein-1.

RNA (New York, N.Y.) - 1 Oct 1997

Schlegl J, Gegout V, Schläger B, Hentze M W, Westhof E, Ehresmann C, Ehresmann B, Romby P

Abstract excerpt

A portion of the 3'UTR of the human transferrin receptor mRNA mediates iron-dependent regulation of mRNA stability. The minimal RNA regulatory region contains three conserved hairpins, so-called iron responsive elements (IREs), that are recognized specifically by iron regulatory proteins (IRPs). The structure of this regulatory region and its complex with IRP-1 was probed using a combination of enzymes and...

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PMID: 9326491
PMCID: PMC1369558

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Probing the structure of the regulatory region of human transferrin receptor messenger RNA and its interaction with iron regulatory protein-1.PMID 9326491Read ↗

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