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Article

Site-directed spin labeling electron paramagnetic resonance study of the ORF1 protein from a mouse L1 retrotransposon.

Protein science : a publication of the Protein Society - 1 Jul 2011

Januszyk Kurt, Fleissner Mark R, Atchabahian Lara, Shieh Fa-Kuen, Altenbach Christian, Martin Sandra L, Guo Feng, Hubbell Wayne L, Clubb Robert T

Abstract excerpt

Long interspersed nuclear element-1 is a highly abundant mammalian retrotransposon that comprises 17% of the human genome. L1 retrotransposition requires the protein encoded by open reading frame-1 (ORF1p), which binds single-stranded RNA with high affinity and functions as a nucleic acid chaperone. ORF1p has been shown to adopt a homo-trimeric, asymmetric dumbbell-shaped structure. However, its atomic-level...

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PMID: 21563223
DOI: 10.1002/pro.651
PMCID: PMC3149196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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