Article
The 5'-untranslated region of human transferrin mRNA, which contains a putative iron-regulatory element, is bound by purified iron-regulatory protein in a sequence-specific manner.
Biochemical and biophysical research communications - 26 Jul 1995
Cox L A, Kennedy M C, Adrian G S
Abstract excerpt
Human transferrin mRNA contains a 5'-untranslated region that (1) has homology to an iron responsive element and (2) is implicated in translational iron regulation of human transferrin transgenes in transgenic mice. Ferritin mRNA contains a 5'-untranslated region iron-responsive element, but iron...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cytoplasm
- Ferritins
- Humans
- In Vitro Techniques
- Iron
- Iron-Regulatory Proteins
- Liver
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- RNA, Messenger
- RNA-Binding Proteins
- Transferrin